Nucleosides and Analogues
Sigma Aldrich Fine Chemicals Biosciences 5-Iodo-2'-deoxyuridine >=99% (HPLC) | 54-42-2 | MFCD00134656 | 25G
5-Iodo-2'-deoxyuridine >=99% (HPLC) | Purity: >=99% (HPLC) | Mol Wt: 354.1 | 54-42-2 | MFCD00134656 | 25G
Apexbio Technology LLC N6-Methyl-ATP 50ul (100 mM)
N6-Methyl-ATP is a methylated derivative of adenosine triphosphate (ATP) designed to function as a selective agonist for purinergic P2 receptors Due to structural modifications including methylation at the N6 position of the adenine moiety this compound displays specificity for interaction with distinct subtypes of P2 purinergic receptors In cellular and molecular research N6-Methyl-ATP is utilized as a pharmacological tool to investigate receptor-mediated signaling pathways particularly ion channel activation calcium influx and associated intracellular signaling cascades modulated through P2 receptors Furthermore it serves as a molecular probe in characterizing purinergic receptor-mediated neurotransmission physiological regulatory processes and receptor subtype distribution in both normal physiological states and pathological conditions contributing to the foundational understanding necessary for receptor-targeted drug discovery
Medchemexpress LLC Uridine | 58-96-8 | MFCD00006526 | 100.0% | 10 G
Uridine is a nucleoside compound composed of uracil and a ribose ring, connected by a β-N1-glycosidic bond. It is for research use only and not sold to patients.
- Inhibits proliferation and induces differentiation of leukemia cells.
- Alleviates liver fibrosis.
- Exhibits anti-ischemic, antioxidant, and anti-arrhythmic effects.
Aat Bioquest NAADP-AM (250 ug)
NAADP nicotinic acid adenine dinucleotide phosphate is a recently discovered second messenger. This catalog is for 250 ug.
Abcam Iodotubercidin, adenosine kinase inhibitor, 1MG
MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC NAD+ 53-84-9 10mM (in 1mL H2O)
Nicotinamide adenine dinucleotide (NAD CAS number 53-84-9) is a coenzyme involved in oxidation-reduction reactions accepting electrons to form NADH Additionally NAD functions as a substrate in enzymatic processes mediated by poly(ADP-ribose) polymerases sirtuins and cyclic ADP-ribose synthases NAD analogs demonstrate inhibitory activity against CD38-associated NAD glycohydrolase (NADase) with reported IC50 values ranging from 2 mM to 10 mM In biomedical research NAD supplementation is investigated for addressing fatigue and fatigue-associated disorders
Medchemexpress LLC 2'-Deoxyguanosine monohydrate | 312693-72-4 | 99.7% | 5 G
2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and 2'-deoxyribose, and it is one of the basic structural units of DNA.
- The oxidation products may participate in DNA damage.
- May affect gene expression or induce cancer.
Medchemexpress LLC Riboflavin 5'-(trihydrogen diphosphate), P'→5'-ester with adenosine | 146-14-5 | 98.9% | 5 MG
Flavin adenine dinucleotide (FAD) is a redox cofactor and prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. It targets endogenous metabolites and functions within the metabolic enzyme/protease pathway. It is soluble in H2O at ≥ 100 mg/mL (127.30 mM). It should be stored at 4°C, protected from light. In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month, also protected from light.
Medchemexpress LLC Flavin adenine dinucleotide disodium salt | 84366-81-4 | MFCD00005041 | 99.72% | 500 UG
Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, specifically a prosthetic group of a protein, that participates in several important enzymatic reactions in metabolism. It is for research use only.
- Redox cofactor
- Prosthetic group of a protein
- Involved in several important enzymatic reactions in metabolism
Medchemexpress LLC Adenosine receptor antagonist 2 | 2703054-47-9 | 99.4% | C23H21FN8O | 25 MG
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. It exhibits anti-tumor activity and has been shown to inhibit tumor growth in vivo.
- Orally active A2a/A2b adenosine receptor antagonist
- Potent inhibition: IC50s of 1 nM (A2a) and 3 nM (A2b)
- Exhibits anti-tumor activity
- Inhibits tumor growth in female C57BL/6 mice
- Molecular weight: 444.46
Medchemexpress LLC 2'-Deoxyguanosine monohydrate | 312693-72-4 | 99.7% | 1 G
2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and 2'-deoxyribose, serving as one of the basic structural units of DNA. Its oxidation products may participate in DNA damage, which can affect gene expression or induce cancer.
- Purity: 99.70%
- Appearance: Solid
- Color: White to off-white
- For research use only
- Molecular weight: 285.26
- Formula: C10H15N5O5
- Human endogenous metabolite
Medchemexpress LLC NBI-961 (formerly CMP3a) | 2225902-98-5 | 99.7% | 568.61 g/mol | C28H27F3N6O2S | 10 MG
NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation and induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells. It is supplied as a solid, light yellow to yellow research-use-only compound and is available in small amounts for laboratory studies.
- High purity (99.7%).
- Molecular weight 568.61 g/mol.
- Chemical formula C28H27F3N6O2S.
- Soluble in DMSO at 100 mg/mL (requires ultrasonic).
- Powder storage: -20°C for 3 years; 4°C for 2 years.
- Intended for laboratory research use only; not for human or animal use.
Medchemexpress LLC Adenosine (Adenine riboside) | 58-61-7 | 99.9% | 100 MG
Adenosine (Adenine riboside) is a ubiquitous, BBB-permeable endogenous autacoid. It acts via four G protein-coupled receptors (A1, A2A, A2B, A3), influencing neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Acts through G protein-coupled receptors: A1, A2A, A2B, and A3.
- Exhibits cytoprotective function.
- Functions as an extracellular signaling molecule derived from ATP and AMP.
- At high concentrations, it shows cytotoxic effects, inhibits cell viability, and triggers ER stress.
- Induces apoptosis in various cancer cells.
- Induces autophagy and activates the AMPK/mTOR pathway to reduce ER stress and apoptotic cell death.
- Cited in clinical trials for myocardial ischemia, coronary artery disease, heart failure, and various cancers.
Medchemexpress LLC Adenosine (standard) | 58-61-7 | >99.4% | 100 MG
Adenosine (Standard) is the analytical standard of Adenosine, intended for research and analytical applications. Adenosine (Adenine riboside) is a ubiquitous endogenous autacoid that influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Analytical standard for research and analytical applications
- Acts through G protein-coupled receptors A1, A2A, A2B, and A3
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
Medchemexpress LLC D-(+)-glucosamine hydrochloride | 66-84-2 | 215.63 | 50 MG
Glucosamine hydrochloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, also used as a dietary supplement. It is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, exerting pharmacological effects on osteoarthritic cartilage and chondrocytes. This product exhibits dose-dependent DPPH antioxidant activity and inhibits HIF-1α at the protein level.
- Exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.
- Exhibits dose-dependent DPPH antioxidant activity.
- Inhibits HIF-1α at the protein level.
- Decreases phosphorylation of p70S6K and S6, translation-related proteins.
- Decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in obstructed kidneys and TGF-β1-treated renal cells.